Publications

An up to date list of my publications. My google scholar profile can be viewed here.

2002     2003     2004     2006     2007     2008     2009     2010     2011     2012      2013      2014      2015     2016     2017


2017

  1. Liu H, MacMillan EL, Jutzeler C, Ljungberg E, MacKay AL, Kolind SH, Mädler B, Li DKB, Dvorak M, Curt A, and Laule C, Kramer JK. Assessing Structure and Function of Myelin in Cervical Spondylotic Myelopathy: Evidence of Demyelination. Neurology. 2017, Aug 8;89(6):602-610.
  2. Vavasour IM, Huijskens SC, Li DK, Traboulsee AL, Mädler B, Kolind SH, Rauscher A, Moore GW, MacKay AL, Laule C. Global loss of myelin water over 5 years in multiple sclerosis normal-appearing white matter. Mult Scler. 2017 Aug 1. [Epub ahead of print].
  3. Laule C, Bjarnason TA, Vavasour IM, Traboulsee AL, Wayne Moore GR, Li DKB, MacKay AL. Characterization of brain tumours with spin-spin relaxation: pilot case study reveals unique T 2 distribution profiles of glioblastoma, oligodendroglioma and meningioma. J Neurol. 2017 Sep 11. [Epub ahead of print].


2016

  1. Neva JL, Lakhani B, Brown KE, Wadden KP, Mang CS, Ledwell NH, Borich MR, Vavasour IM, Laule C, Traboulsee AL, MacKay AL, Boyd LA. Multiple measures of corticospinal excitability are associated with clinical features of multiple sclerosis. Behav Brain Res. 2016 Jan 15;297:187-95.
  2. Meyers SM, Kolind SH, Laule C, MacKay AL. Measuring Water Content using T2 Relaxation at 3T: Phantom Validations and Simulations. Magnetic Resonance Imaging. Magn Reson Imaging. 2016 Apr;34(3):246-51.
  3. Moore GRW, Laule C, Leung E, Pavlova V, Morgan BP, Esiri MM. Complement and humoral adaptive immunity in the human choroid plexus: roles for stromal concretions, basement membranes and epithelium. Journal of Neuropathology and Experimental Neurology. J Neuropathol Exp Neurol. 2016 May;75(5):415-28.
  4. Meyers SM, Tam R, Lee JS, Kolind SH, Vavasour IM, Mackie E, Zhao Y, Laule C, Mädler B, Li DK, MacKay AL, Traboulsee AL. Does hydration status affect MRI measures of brain volume or water content? Journal of Magnetic Resonance Imaging. J Magn Reson Imaging. 2016 Aug;44(2):296-304.
  5. Laule C, Yung A, Pavolva V, Bohnet B, Kozlowski P, Hashimoto SA, Yip S, Li DK, Moore GRW. High-resolution myelin water imaging in post-mortem multiple sclerosis spinal cord: A case report. Multiple Sclerosis. 2016 Oct;22(11):1485-1489.
  6. Laule C and MacKay AL. Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin. Brain Plasticity. 2016 (2)1: pp. 71-91. (Invited Review)


2015

  1. Zhang J, Kolind SH, Laule C, MacKay AL. Comparison of Myelin Water Fraction from Multi-echo T2 Decay Curve and Steady-state Methods. Magnetic Resonance in Medicine. 2015 Jan;73(1) 223-32.
  2. Sturrock A, Laule C, Wyper K, Milner RA, Decolongon J, Dar Santos R, Coleman AJ, Carter K, Creighton S, Bechtel N, Bohlen S, Reilmann R, Johnson HJ, Hayden MR, Tabrizi SJ, Mackay AL, Leavitt BR. A longitudinal study of magnetic resonance spectroscopy Huntington’s disease biomarkers.Mov Disord. 2015 Mar;30(3):393-401.
  3. Barta R, Kalantari S, Laule C, Vavasour IM, MacKay AL, Michal CA. Modeling T1 and T2 relaxation in bovine white matter.J Magn Reson. 2015 Oct;259:56-67.
  4. Zhang J, Kolind SH, Laule C, MacKay AL. How does magnetization transfer influence mcDESPOT results? Magnetic Resonance in Medicine. 2015 Nov;74(5):1327-35


2014

  1. Lang DJ-M, Yip E, MacKay AL, Thornton AE, Vila-Rodriguez F, MacEwan GW, Kopala LC, Smith GN, Laule C, MacRae CB, Honer WG. 48 echo T₂ myelin imaging of white matter in first-episode schizophrenia: evidence for aberrant myelination. Neuroimage Clin. 2014 Oct 15;6:408-14
  2. MacKay AL, Laule C, Li DKB, Meyers SM, Russell-Schulz B, Vavasour IM. Magnetic resonance techniques for investigation of multiple sclerosis. American Institute of Physics Proceedings, Volume 1032, pages 60-69 (2014) (Invited Review)


2013

  1. Laule C, Pavlova V, Leung E, Zhao G, MacKay AL, Kozlowski P, Traboulsee AL, Li DKB, Moore GRW. Diffusely Abnormal White Matter in Multiple Sclerosis: Further Histological Studies Provide Evidence for a Primary Lipid Abnormality with Neurodegeneration. Journal of Neuropathology and Experimental Neurology, 2013 Jan;72(1):42-52
  2. Sharp ME, Laule C, Nantel S, Mädler B, Aul RB, Yip S, Sirrs S. Stem Cell Transplantation for Adult-Onset Krabbe Disease: Report of a Case. Journal of Inherited Metabolic Disease, 2013;10:57-9.
  3. Russell-Schulz B, Laule C, Li DKB, MacKay AL. What causes the hyperintense T2-weighting and increased short T2 signal in the corticospinal tract? Magnetic Resonance Imaging. 2013 Apr;31(3):329-35
  4. Bjarnason TA, Laule C, Bluman J, Kozlowski P. Temporal phase correction of multiple echo T2 magnetic resonance images. Journal of Magnetic Resonance, 2013 Jun;231:22-31
  5. Zhang Y, Moore GRW, Laule C, Bjarnason TA, Kozlowski P, Traboulsee AL, Li DKB. Pathological correlates of MRI texture heterogeneity in multiple sclerosis. Annals of Neurology. 2013 Jul;74(1):91-9
  6. Wiggermann V, Hernandez Torres E, Vavasour IM, Moore GRW, Laule C, MacKay AL, Li DKB, Traboulsee AL, Rauscher A. Magnetic resonance frequency shifts during acute MS lesion formation. Neurology. 2013 Jul 16;81(3):211-8
  7. Meyers SM, Vavasour IM, Mädler B, Harris T, Fu E, Li DK, Traboulsee AL, Mackay AL, Laule C. Multicenter measurements of myelin water fraction and geometric mean T2 : Intra- and intersite reproducibility. Journal of Magnetic Resonance Imaging, 2013 Dec;38(6):1445-53


2012

  1. Liang AL, Vavasour IM, Maedler M, Traboulsee AL, Lang DJ, Li DKB, MacKay AL, Laule C. Short-term stability of T1 and T2 relaxation measures in multiple sclerosis normal appearing white matter. Journal of Neurology 2012 Jun;259(6):1151-1158
  2. Moore GRW and Laule C. Neuropathologic Correlates of Magnetic Resonance Imaging in Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology. 2012 Sep;71(9):762-778 (Invited Review)
  3. Prasloski T, Rauscher A, MacKay AL, Hodgson M, Vavasour IM, Laule C, Maedler B. Whole Cerebrum Myelin Water Imaging. Neuroimage 2012 Oct 15;63(1): 533-539


2011

  1. Vavasour IM, Laule C, Li DKB, Traboulsee AL, MacKay AL. Is the magnetization transfer ratio a marker for myelin in multiple sclerosis tissue? Journal of Magnetic Resonance Imaging, 2011 Mar; 33(3) 713-718.
  2. Kalantari S, Laule C, Bjarnason TA, MacKay AL. In-vivo insights into magnetization exchange in human white matter structures. Magnetic Resonance in Medicine 2011 Oct; 66(4) 1142-1151
  3. Laule C, Vavasour IM, Leung E, Li DKB, Kozlowski P, Traboulsee AL, Oger J, MacKay AL, Moore GRW. Pathological Basis of Diffusely Abnormal White Matter: Insights from Magnetic Resonance Imaging and Histology. Multiple Sclerosis 2011 Feb;17(2): 144-150.  


2010

  1. Laule C, Vavasour IM, Vavasour JD, Oger J, Paty DW, MacKay AL, Li DKB. Cervical Cord Abnormalities in Primary Progressive Multiple Sclerosis: Atrophy and Myelin Water Changes. Mult Scler. 2010 Jun;16(6):670-677
  2. Brief EE, Vavasour IM, Laule C, Li DKB, MacKay AL. Proton MRS of Large MS Lesions Reveals Subtle Changes in Metabolite T1 and Area NMR Biomed. 2010 Nov;23(9):1033-1037
  3. Laule C, Tahir S, Chia CLL, Vavasour IM, Kitson N, MacKay AL. A proton NMR study on the hydration of normal versus psoriatic stratum corneum: linking distinguishable reservoirs to anatomical structures NMR Biomed. 2010 Dec;23(10):1181-1190
  4. Sturrock A*, Laule C*, Decolongon J, Dar Santos R, Coleman AJ, Creighton S, Bechtel N, Reilmann R, Hayden MR, Tabrizi SJ, Mackay AL, Leavitt BR. Magnetic Resonance Spectroscopy Biomarkers in Pre-manifest and Early Huntington’s Disease Neurology, 2010 Nov 9;75(19):1702-1710. *joint first authors


2009

  1. Vavasour IM, Laule C, Li DKB, Oger J, Moore GRW, Traboulsee AL, MacKay AL, Paty DW. Longitudinal changes in myelin water fraction in two MS patients with active disease. J Neurol Sci. 2009 Jan 15;276(1-2):49-53.
  2. MacKay AL, Vavasour IM, Rauscher A, Kolind SH, Mädler B, Moore GRW, Traboulsee AL, Li DK, Laule C MR relaxation in multiple sclerosis. Neuroimaging Clin N Am. 2009 Feb;19(1):1-26. (Invited Review)
  3. Minty EP, Laule C, Bjarnason TA, MacKay AL. Myelin Water Measurement in Spinal Cord. Magn Reson Med. 2009 Apr;61(4):883-92.
  4. Meyers S, Laule C, Vavasouor IM, Kolind SH, Maedler B, Tam R, Traboulsee AL, Lee J, Li DKB, MacKay AL. Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods Magn Reson Imaging. 2009 Oct;27(8):1096-103
  5. Vitali AM, Moore GRW, Leung E, Laule C, Kozlowski P, MacKay AL. Thalamic stimulation in multiple sclerosis: an imaging and pathological post-mortem case study. Mult Scler. 2009 Nov;15(11):1311-21


2008

  1. Kolind SH, Laule C, Vavasour IM, Li DKB, Traboulsee AL, Maedler B, Moore GRW, MacKay AL. Complimentary Information from Multi-Exponential T2 Relaxation and Diffusion Tensor Imaging Reveals Differences between Multiple Sclerosis Lesions. NeuroImage 2008 Mar 1;40(1):77-85
  2. Laule C, Kozlowski P, Leung E, Li DKB, MacKay AL, Moore GRW.  Myelin Water Imaging of Multiple Sclerosis at 7T: Correlations with Histopathology. Neuroimage 40:1575-1580, 2008
  3. MacKay AL, Laule C, Maedler B, Rauscher A, Vavasour IM. Studying Multiple Sclerosis with Magnetic Resonance. American Institute of Physics Proceedings, Volume 1032, pages 60-69 (2008) (Invited Review)
  4. Moore GRW, Laule C, MacKay AL, Leung E, Li DKB, Zhao G, Traboulsee AL, Paty DW. Dirty-appearing White Matter in Multiple Sclerosis: Preliminary Observations of Myelin Phospholipid and Axonal Loss. J Neurol. 2008 Nov;255(11):1802-11, discussion 1812


2007

  1. Sirrs SM, Laule C, Maedler B, Brief EE, Tahir SA, Bishop C, MacKay AL. Normal appearing white matter in subjects with phenylketonuria: water content, myelin water fraction, and metabolite concentrations. Radiology 2007;242(1):236-243.
  2. Laule C, Kolind SH, Bjarnason TA, Li DK, Mackay AL. In vivo multiecho T(2) relaxation measurements using variable TR to decrease scan time. Magn Reson Imaging 2007;25(6):834-839.
  3. Laule C, Vavasour IM, Kolind SH, Li DK, Traboulsee TL, Moore GR, Mackay AL. Magnetic resonance imaging of myelin. Neurotherapeutics 2007;4(3):460-484. (Invited Review)
  4. Laule C, Vavasour IM, Maedler B, Kolind SH, Sirrs SM, Brief EE, Traboulsee AL, Moore GRW, Li DKB, MacKay AL. MR Evidence of Long T2 Water in Pathological White Matter Journal of Magnetic Resonance Imaging 2007; Oct 26(4),1117-1121.
  5. Laule C, Vavasour IM, Kolind SH, Traboulsee AL, Moore GRW, Li DKB, MacKay AL. Long T2 Water in Multiple Sclerosis: What else can we learn from multi-echo T2 Relaxation? Journal of Neurology 2007; Nov;254(11):1579-87.
  6. Vavasour IM, Li DKB, Laule C, Traboulsee AL, Moore GRW, MacKay AL. Multi-parametric MR assessment of T1 black holes in multiple sclerosis: Evidence that myelin loss is not greater in hypointense versus isointense T1 lesions. Journal of Neurology 2007; Dec;254(12):1653-9


2006

  1. Laule C, Leung E, Lis DK, Traboulsee AL, Paty DW, MacKay AL, Moore GR. Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology. Mult Scler 2006;12(6):747-753.
  2. MacKay A, Laule C, Vavasour I, Bjarnason T, Kolind S, Madler B. Insights into brain microstructure from the T2 distribution. Magn Reson Imaging 2006;24(4):515-525.


2004

  1. Laule C, Vavasour IM, Moore GRW, Oger J, Li DKB, Paty DW, MacKay AL. Water content and myelin water fraction in multiple sclerosis: A T2 relaxation study. Journal of Neurology 2004;251(3):284-293.
  2. Li D, Laule C, Vavasour I, Vavasour J, Whittall K, MacKay A. Cervical cord atrophy assessment on magnetic resonance imaging: PROMiSe trial. Mult Scler 2004;10(Suppl 1):S79-80.


2003

  1. Laule C, Vavasour IM, Whittall KP, Oger J, Paty DW, Li DK, MacKay AL, Arnold DL. Evolution of focal and diffuse magnetisation transfer abnormalities in multiple sclerosis. Journal of Neurology 2003;250(8):924-931.


2002

  1. MacKay AL, Laule C, Maedler B, Vavasour IM, Whittall KP. Magnetic Resonance Distinguishes Different Water Reservoirs in Brain. Physics in Canada 2002;58(2):135-143. (Invited Review)